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Updated: Jul 6, 2026

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
Vicinal functionalization of propiolate esters via a tandem catalytic carbocupration-Mukaiyama aldol reaction
Amanda J Mueller1, Michael P Jennings
1Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA.
Abstract:
The vicinal functionalization of propiolate esters via a tandem catalytic carbocupration-Mukaiyama aldol reaction sequence has been investigated. It has been shown that catalyst loadings as low as 8 mol % readily allow for good yields and excellent diastereoselectivities (>20:1) for a series of Grignard reagents and aldehydes.
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