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Updated: Jul 6, 2026

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
Published on: October 3, 2010
Therapeutic targets for medulloblastoma
Pawel K Wlodarski1, Jaroslaw Jozwiak
1Medical University of Warsaw, Center for Biostructure Research, Department of Histology and Embryology, Poland. pawel.wlodarski@am.edu.pl
Background:
Present treatment of medulloblastoma, the most common malignant brain tumor in children, includes surgery, radiotherapy and chemotherapy. In spite of radical treatment, only about 70% of patients survive. Also side effects of the treatment are severe, mostly due to applied radiotherapy.
Objective:
The following review highlights potential molecular targets for pharmacotherapy of medulloblastoma, as well as the directions in which, in the authors' opinion, the field will evolve in near future.
Methods:
Present literature on pathways engaged in formation of medulloblastoma is summarized in the context of their available pharmacological modulators.
Results:
The quest for a better treatment modalities includes better risk stratification methods, including molecular profiling of individual tumors and a search for new small molecules capable of inhibiting hyperactive signaling pathways. Several candidates for such agents are being tested presently.
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