[Correlations among FPB beta 15-42, PAC and D-dimer]

Area of Science:

• Biochemistry
• Hematology
• Clinical Chemistry

Background:

• Secondary fibrinolysis is a complex process observed in various clinical conditions.
• Disseminated intravascular coagulation (DIC) is characterized by dysregulated fibrinolysis.
• Accurate assessment of plasmin activity is crucial for managing patients with bleeding or thrombotic disorders.

Purpose of the Study:

• To evaluate the utility of specific molecular markers of plasmin activity in patients with subarachnoid hemorrhage, trauma, and during cardiopulmonary bypass.
• To compare the diagnostic value of FPB beta 15-42 and alpha 2 plasmin inhibitor-plasmin-complex (PAC) in identifying secondary fibrinolysis, particularly in patients with DIC.
• To determine the correlation between these markers and D-dimer in different patient cohorts.

Main Methods:

• Measurement of FPB beta 15-42, alpha 2 plasmin inhibitor-plasmin-complex (PAC), and D-dimer in 204 patient samples.
• Analysis of molecular marker levels in patients with subarachnoid hemorrhage, trauma, cardiopulmonary bypass, and DIC.
• Statistical analysis to assess correlations among the measured markers, with a focus on DIC patients.

Main Results:

• All measured molecular markers of plasmin activity increased in the studied patient groups due to secondary fibrinolysis.
• Increases in FPB beta 15-42, PAC, and D-dimer were significantly higher in patients diagnosed with DIC.
• A stronger positive correlation was observed between FPB beta 15-42 and D-dimer compared to PAC and D-dimer in DIC patients.

Conclusions:

• FPB beta 15-42 and PAC are valuable indicators of plasmin activity and secondary fibrinolysis.
• The distinct correlation patterns with D-dimer suggest that measuring both FPB beta 15-42 and PAC may offer a more comprehensive assessment of plasmin activity in DIC.
• Combined measurement of FPB beta 15-42 and PAC could improve the diagnostic accuracy and management of DIC.