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NAT2*7 allele is a potential risk factor for adult brain tumors in Taiwanese population

H Eugene Liu1, Pei-Yu Hsiao, Ching-Chen Lee

  • 1Graduate Institute of Clinical Science, Taipei Medical University, 250, Wushing Street, Taipei, Taiwan 116, People's Republic of China.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
|March 20, 2008
PubMed

Insights

The NAT2*7 genetic variant may increase brain tumor risk. This study found a higher frequency of the NAT2*7 allele in Taiwanese brain tumor patients, suggesting it

Area of Science:

  • Genetics
  • Oncology
  • Pharmacogenomics

Background:

  • Arylamine N-acetyltransferase-2 (NAT2) genetic variations influence drug and carcinogen metabolism.
  • The link between NAT2 polymorphisms and adult brain tumors remains largely undetermined.

Purpose of the Study:

  • To investigate if NAT2 genotype is a risk factor for brain tumors.
  • To determine the frequencies of common NAT2 polymorphisms (NAT2*5, NAT2*6, NAT2*7) in brain tumor patients and controls.

Main Methods:

  • Genotyping of three common NAT2 polymorphisms (NAT2*5, NAT2*6, NAT2*7) using PCR-RFLP.
  • Phenotyping subjects as fast or slow acetylators based on their genotypes.
  • Comparing allele frequencies between 27 brain tumor patients and 27 age/gender-matched controls.

Main Results:

  • The NAT2*7 allele frequency was significantly higher in brain tumor patients (OR, 6.786; P = 0.003).
  • The NAT2*4/*7 genotype was more prevalent in the patient group (OR, 6.19; P = 0.0039).
  • NAT2*7 allele presence was associated with high-grade astrocytoma or glioblastoma multiforme (P = 0.016).

Conclusions:

  • The NAT2*7 allele may represent a potential risk factor for brain tumor development.
  • Findings suggest a specific genetic predisposition to brain tumors in the Taiwanese population.

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