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Establishing outcome domains for evaluating treatment of acute and chronic gout
Rebecca Grainger1, William J Taylor
1Department of Medicine, Wellington School of Medicine & Health Sciences, University of Otago, Wellington 6242, New Zealand.
Purpose Of Review:
Novel therapies for gout have recently been developed which has prompted considerable efforts in defining the relevant outcomes for measurement in intervention trials of gout. This review summarizes the consensus exercises refining domains for measurement and the work of individual groups in assessment of the validity of measurement tools for these domains.
Recent Findings:
Recent publications have focused on the consensus exercises and validation studies of measurement tools, particularly in relation to tophus size and imaging.
Summary:
Consensus on potential outcome domains has been achieved, but measuring these domains requires further validation in observational studies and confirmation of relevance from people with gout. Further work is also required in refining measurements of tophus size and imaging scores. The role of a response criteria measure is also yet to be defined, especially in relation to reduction in flare frequency, or whether composite criteria are necessary.
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Guidelines for Writing Outcome
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care evaluation by...
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