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Related Experiment Video

Updated: Jul 6, 2026

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition
07:45

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Published on: July 21, 2020

BOLD-perfusion coupling during monocular and binocular stimulation.

Claudine Gauthier1, Richard D Hoge

  • 1Unité de Neuroimagerie Fonctionnelle, Institut Universitairy of Gériatrie de Montréal, Montreal, QC, Canada H3W 1W5.

International Journal of Biomedical Imaging
|March 20, 2008
PubMed
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This study investigated the relationship between blood oxygenation level-dependent (BOLD) signals and blood flow during visual stimulation. Results indicate that BOLD-perfusion coupling remains consistent, challenging theories of mismatched responses in the visual cortex.

Area of Science:

  • Neuroscience
  • Visual Cortex Research
  • Functional Neuroimaging

Background:

  • Previous research suggested differential BOLD signal responses during monocular vs. binocular stimulation.
  • This was hypothesized to stem from uniform perfusion increases alongside localized metabolic increases in visual cortex columns.

Purpose of the Study:

  • To test the hypothesis of a BOLD-perfusion coupling mismatch during monocular stimulation.
  • To measure BOLD-perfusion coupling ratios in the primary visual cortex (V1) under different visual input conditions.

Main Methods:

  • Utilized functional magnetic resonance imaging (fMRI) to measure BOLD and perfusion signals.
  • Compared these signals during monocular and binocular visual stimulation in human participants.

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Last Updated: Jul 6, 2026

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition
07:45

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Published on: July 21, 2020

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
08:42

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex

Published on: February 8, 2020

Main Results:

  • Withholding input from one eye caused significant decreases in V1 BOLD and perfusion signals.
  • Crucially, the ratio between BOLD signal increases and perfusion increases did not significantly change between monocular and binocular stimulation.

Conclusions:

  • The findings do not support a significant mismatch in the spatial patterns of blood flow and oxidative metabolism during monocular stimulation.
  • The study suggests a more uniform coupling between BOLD and perfusion signals in V1, irrespective of stimulation type.