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Do different vaccination regimens for BCG and hepatitis B affect the development of allergic disorders in early

Dilek Dilli1, Ilknur Bostanci, Yildiz Dallar

  • 1Department of Paediatrics, Ministry of Health, Ankara Training and Research Hospital, Ankara, Turkey. dilekdilli2@yahoo.com

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|March 20, 2008
PubMed

Insights

The timing of early childhood vaccinations, specifically the bacilli Calmette-Guérin (BCG) vaccine and hepatitis B vaccine, may influence the risk of recurrent wheezing. BCG vaccination at birth and hepatitis B at two months appears protective against this condition.

Area of Science:

  • Pediatric immunology
  • Vaccinology
  • Allergy and immunology

Background:

  • Atopy and allergic disorders are common in early childhood.
  • The timing of infant vaccinations, including BCG and hepatitis B, is a critical public health consideration.
  • Understanding the impact of vaccination schedules on immune development is essential.

Purpose of the Study:

  • To investigate the effect of the age of bacilli Calmette-Guérin (BCG) and hepatitis B vaccination on the development of atopy and allergic disorders.
  • To compare immune responses and allergy development based on different vaccination timings in infants.

Main Methods:

  • A cross-sectional study involving 109 children aged 24-36 months with respiratory issues.
  • Participants were divided into two groups based on vaccination schedules: BCG at two months/hepatitis B at birth, or BCG at birth/hepatitis B at two months.
  • Atopic status was evaluated using skin-prick tests (SPTs).

Main Results:

  • No significant difference in atopy prevalence was observed between the two vaccination groups (p = 0.27).
  • Recurrent wheezing was more prevalent in the group receiving hepatitis B at birth and BCG at two months (36.4%) compared to the other group (16.3%, p = 0.04).
  • Logistic regression indicated that BCG at birth and hepatitis B at two months was protective against recurrent wheezing (OR 0.5; CI: 0.3-0.8; p = 0.01).

Conclusions:

  • Administering the BCG vaccine at birth and the hepatitis B vaccine at two months may offer protection against recurrent wheezing in early childhood.
  • This specific vaccination timing does not appear to prevent the development of atopy.
  • Further research is warranted to elucidate the immunological mechanisms underlying these findings.
Abstract

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