Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...

Structure of Cardiac Muscles

Structure of Cardiac Muscles

Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

Specialized Characteristics of Cardiac Muscles

Specialized Characteristics of Cardiac Muscles

The primary role of cardiac muscles is to propel blood throughout the cardiovascular system. The cardiac muscle cells, or cardiomyocytes, exhibit specialized characteristics that allow them to perform this function.
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy reserves in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multiple Left Ventricular Ball Thrombi in a Patient With Nonischemic Cardiomyopathy Bridged to Heart-Lung Transplantation.

JACC. Case reports·2025

Same author

Genetically engineered pig heart transplantation in non-human primates.

Communications medicine·2025

Same author

Transplantation of a genetically modified porcine heart into a live human.

Nature medicine·2025

Same author

Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report.

Lancet (London, England)·2023

Same author

Dataset for the reporting of neoplasms of the heart, pericardium, and great vessels: recommendations from the International Collaboration on Cancer Reporting (ICCR).

Virchows Archiv : an international journal of pathology·2022

Same author

Nivolumab-induced peritonitis with peritoneal mesothelial hyperplasia mimicking metastatic mesothelioma.

AJSP: reviews & reports·2022

Search research articles

Related Experiment Video

Updated: Jul 6, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Primary malignant cardiac tumors.

¹CVPath Institute, Gaithersburg, Maryland 20878, USA. aburke@cvpath.org

Seminars in Diagnostic Pathology

|March 21, 2008

Summary

Malignant heart tumors are rare, with sarcomas being the most common type, often misdiagnosed as myxoma. These sarcomas exhibit diverse histology and specific locations within the heart chambers.

Area of Science:

Cardiovascular Pathology
Surgical Oncology

Background:

Malignant tumors constitute about 10% of surgically resected cardiac masses.
Sarcomas represent over 90% of these malignant cardiac tumors, with lymphomas being less common.

Purpose of the Study:

To detail the histological characteristics and common locations of primary cardiac sarcomas.
To differentiate cardiac sarcomas from other cardiac tumors, particularly myxomas.

Main Methods:

Review of surgically resected heart tumors.
Histopathological analysis of malignant cardiac neoplasms.
Correlation of tumor location with histological type.

Main Results:

Cardiac sarcomas are the predominant malignant heart tumor type.

Related Experiment Videos

Last Updated: Jul 6, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Angiosarcomas typically occur in the right atrium.

Other sarcomas, often pleomorphic with potential osteosarcoma or chondrosarcoma components, are frequently found in the left atrium and can mimic myxoma.

Conclusions:

Primary cardiac sarcomas are a significant subgroup of malignant heart tumors.
Accurate histological diagnosis and understanding of anatomical predilection are crucial for managing these rare malignancies.