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[Naproxen-induced bullous photodermatitis (pseudoporphyria)]
1Hudavdelingen, Rikshospitalet, Oslo.
Summary
Two cases of naproxen-induced bullous photodermatitis, a skin condition causing blisters, were reported. Symptoms resolved after discontinuing naproxen, highlighting a potential drug-induced phototoxic reaction.
Area of Science:
- Dermatology
- Photomedicine
- Toxicology
Background:
- Pseudoporphyria, characterized by skin fragility and blisters, can mimic porphyria cutanea tarda but lacks associated hematological abnormalities.
- Photodermatitis can result from phototoxic reactions to medications or other chromophores, and is observed in hemodialysis patients and UVA-sunbed users.
Observation:
- Two distinct cases of bullous photodermatitis (pseudoporphyria) were observed, presenting with recurrent blisters and skin fragility on the hands and face.
- The clinical and histological presentation of these cases were indistinguishable from porphyria cutanea tarda.
Findings:
- Naproxen was identified as the causative agent, with symptoms resolving completely upon its cessation.
- This represents the first reported instance of naproxen-induced pseudoporphyria in Norway.
Implications:
- Naproxen should be considered as a potential cause of pseudoporphyria, particularly in patients with unexplained blistering photodermatitis.
- Clinicians should inquire about naproxen use in patients presenting with symptoms suggestive of pseudoporphyria.
- Further research into drug-induced phototoxic reactions is warranted to better understand and manage conditions like pseudoporphyria.