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Recurrent venous thrombosis and hypercoagulable states.

C D Bolan1, B M Alving

  • 1Womack Army Community Hospital, Fort Bragg, North Carolina.

American Family Physician
|November 1, 1991
PubMed
Summary

Recurrent venous thrombosis may indicate inherited hypercoagulable disorders like protein S, protein C, or antithrombin III deficiencies. Anticoagulation therapy is key for managing both inherited and acquired thrombotic risks.

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Area of Science:

  • Hematology
  • Genetics
  • Internal Medicine

Background:

  • Recurrent venous thrombosis and early-onset thrombosis with family history suggest inherited hypercoagulable states.
  • Common inherited disorders include deficiencies in coagulation inhibitors: protein S, protein C, and antithrombin III.

Observation:

  • Approximately 10% of young patients (<45 years) with venous thrombosis have these deficiencies.
  • Acquired causes of recurrent thrombosis include carcinoma and antiphospholipid antibody syndrome.

Findings:

  • Inherited deficiencies of protein S, protein C, and antithrombin III are significant risk factors for venous thrombosis.
  • Carcinoma and antiphospholipid antibody syndrome are identified as acquired causes of recurrent thrombotic events.

Implications:

  • Identifying inherited and acquired hypercoagulable disorders is crucial for patient management.
  • Effective anticoagulation strategies can mitigate the risk of recurrent thrombosis in affected individuals.

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