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Thyroid storm caused by a partial hydatidiform mole

Niyati U Chiniwala1, Paul D Woolf, Christopher P Bruno

  • 1Department of Medicine, Crozer Chester Medical Center, Upland, Pennsylvania 19013, USA. niyatichiniwala@gmail.com

Thyroid : Official Journal of the American Thyroid Association
|March 21, 2008
PubMed

Clinical thyrotoxicosis is rare in molar pregnancy and has yet to be reported in a patient with a partial mole. Human chorionic gonadotropin (hCG), which has thyrotropic activity, is believed to be responsible for hyperthyroidism of gestational trophoblastic activity and hyperemesis gravidarum. We report the first case of hyperthyroidism presenting as thyroid storm in a partial molar pregnancy. Normal thyroid function returned after the partial mole was evacuated, and the biochemical improvement correlated with declining hCG levels. This case highlights the importance of including partial mole in the differential of hCG-mediated hyperthyroidism.

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