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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...

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Updated: Jul 6, 2026

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice

Published on: January 31, 2020

Etanercept.

Erin Ducharme¹, Jeffrey M Weinberg

¹St. Luke's-Roosevelt Hospital Center, Department of Dermatology, 1090 Amsterdam Avenue, Suite 11D, New York, NY 10025, USA.

Expert Opinion on Biological Therapy

|March 21, 2008

Summary

This summary is machine-generated.

Etanercept effectively treats psoriasis and psoriatic arthritis by targeting TNF-alpha. This review covers its efficacy, off-label uses, and safety profile for these inflammatory conditions.

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Last Updated: Jul 6, 2026

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice

Published on: January 31, 2020

Area of Science:

Immunology
Dermatology
Rheumatology

Background:

Psoriasis involves skin and joint inflammation, with TNF-alpha central to pathogenesis.
Etanercept is a biologic therapy targeting TNF-alpha to manage inflammatory diseases.

Purpose of the Study:

Review clinical trials on etanercept for psoriasis and psoriatic arthritis.
Discuss off-label dermatological applications of etanercept.
Describe adverse events associated with etanercept use.

Main Methods:

Literature search of Medline database.
Focused on articles concerning etanercept and psoriasis.

Main Results:

Etanercept demonstrates efficacy for both skin and joint symptoms of psoriatic disease.
FDA-approved for treating psoriasis and psoriatic arthritis.
Off-label dermatological uses show variable success.

Conclusions:

Etanercept is an effective treatment for psoriatic disease manifestations.
The drug has a favorable safety profile with over a decade of use.
Ongoing research explores additional therapeutic applications.