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Clinical experience with DTPw-HBV and DTPw-HBV/Hib combination vaccines

Roman Prymula1, Stanislav Plisek

  • 1University of Defense, Department of Epidemiology, Faculty of Military Health Science, Hradec Kralove, Czech Republic. prymula@pmfhk.cz

Expert Opinion on Biological Therapy
|March 21, 2008
PubMed

Insights

New diphtheria-tetanus-whole-cell pertussis (DTPw) combination vaccines, Zilbrix, use novel antigen sources and reduced polyribosylribitol phosphate (PRP) to ensure continued global supply for childhood immunizations.

Area of Science:

  • Pediatric Vaccinology
  • Immunology
  • Public Health

Background:

  • Combined diphtheria-tetanus-whole-cell pertussis (DTPw) vaccines are essential for childhood immunization programs.
  • DTPw-based combination vaccines offer protection against multiple pathogens, including hepatitis B (HBV) and Haemophilus influenzae type b (Hib).
  • GlaxoSmithKline (GSK) Biologicals developed the Zilbrix range to meet growing demand, featuring a new DTPw antigen source and reduced polyribosylribitol phosphate (PRP).

Purpose of the Study:

  • To present clinical trial results for DTPw-based vaccines.
  • To evaluate the efficacy and safety of the new Zilbrix vaccine range.

Main Methods:

  • A comprehensive data package was provided by GSK Biologicals.
  • A Medline literature search was conducted to supplement the provided data.

Main Results:

  • Clinical trial data demonstrated the immunogenicity of the DTPw-based vaccines.
  • The new antigen source and reduced PRP in the Zilbrix range were found to be effective.

Conclusions:

  • The novel antigen sources and reduced PRP content in the Zilbrix range ensure the continued availability of DTPw-based combination vaccines.
  • These advancements support vital global mass vaccination campaigns for children.
Abstract

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