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Related Experiment Video

Updated: Jul 6, 2026

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy

Published on: May 16, 2015

Neurokinin A level in hypoxic-ischemic encephalopathy.

May F Nassar¹, Hoda L El-Sayed, Nermine T Fouad

¹Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt. maie_nassar@yahoo.co.uk

Pediatrics International : Official Journal of the Japan Pediatric Society

|March 21, 2008

Summary

Neurokinin A (NKA) levels are reduced in neonates with hypoxic-ischemic encephalopathy (HIE), particularly in severe cases. This neurotransmitter may play a role in HIE pathogenesis and its severity.

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Last Updated: Jul 6, 2026

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy

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Published on: November 20, 2015

Area of Science:

Neonatal Neurology
Neuroscience
Biochemistry

Background:

Neonatal hypoxic-ischemic encephalopathy (HIE) is a serious condition affecting newborns.
The neurotransmitter neurokinin A (NKA) role in HIE is not fully understood.

Purpose of the Study:

To investigate the effect of HIE on NKA levels.
To correlate NKA levels with the severity of neonatal hypoxia.

Main Methods:

Compared 18 HIE neonates with 10 healthy controls.
Measured NKA levels in cord blood and post-stabilization using ELISA.
Collected maternal history, delivery details, Apgar scores, and clinical data.

Main Results:

NKA levels were significantly lower in HIE neonates at birth compared to controls.
NKA levels improved in follow-up samples.
Severe hypoxia cases showed the greatest NKA reduction.
NKA at birth correlated positively with Apgar scores and HIE stage.

Conclusions:

NKA levels are decreased in HIE, with severity correlating to hypoxia degree.
NKA may be involved in HIE pathogenesis.
HIE disrupts the neonatal central neuropeptide system.