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Published on: May 4, 2018

Effect of different doses of vitamin D on osteocalcin and deoxypyridinoline in preterm infants

Fatih M Kislal1, Ugur Dilmen

  • 1Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey. fmkislal@hotmail.com

Pediatrics International : Official Journal of the Japan Pediatric Society
|March 21, 2008
PubMed

Insights

High-dose vitamin D supplementation in preterm infants may increase bone turnover, as indicated by elevated urinary deoxypyridinoline (DPD) levels. This study explored different vitamin D doses and their impact on bone metabolism markers.

Area of Science:

  • Pediatrics
  • Neonatology
  • Bone Metabolism

Background:

  • Metabolic bone disease is prevalent in preterm infants.
  • Understanding vitamin D's role in preterm infant bone health is crucial.

Purpose of the Study:

  • To investigate the effects of varying vitamin D doses on bone turnover markers in preterm infants.
  • To examine the relationship between vitamin D intake and urinary deoxypyridinoline (DPD), serum osteocalcin (OC), calcium (Ca), inorganic phosphorus (P), and alkaline phosphatase (ALP).

Main Methods:

  • 37 preterm infants received daily vitamin D doses of 200, 400, or 800 IU/kg from day 15 to 30 of life.
  • Serum Ca, P, ALP, and OC levels were measured, alongside urinary DPD excretion.

Main Results:

  • Serum Ca and P levels showed no significant changes across groups.
  • Serum ALP and OC levels increased in response to vitamin D supplementation.
  • Urinary DPD excretion increased with higher vitamin D doses, significantly in the 800 IU/kg group.

Conclusions:

  • High-dose vitamin D supplementation may accelerate bone turnover in preterm infants.
  • Increased urinary DPD levels suggest enhanced bone resorption with higher vitamin D intake.
  • This study is the first to compare different vitamin D doses using urinary collagen cross-links to assess bone turnover in preterm infants.
Abstract

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