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The international standard for teicoplanin.
1National Institute for Biological Standards and Control, Potters Bar, Herts, U.K.
Summary
An international standard for teicoplanin was established through a collaborative study involving five countries. This standard defines the teicoplanin activity in each ampoule as 51,550 IU.
Area of Science:
- Microbiology and Infectious Diseases
- Pharmacology and Pharmaceutical Sciences
Background:
- Teicoplanin is a crucial glycopeptide antibiotic used in treating serious bacterial infections.
- Establishing a reliable international standard is essential for accurate potency determination and quality control of teicoplanin.
Purpose of the Study:
- To establish an international standard for teicoplanin.
- To define the precise activity of teicoplanin in the international standard preparation.
Main Methods:
- A collaborative study was conducted.
- Five international laboratories participated in the standardization process.
Main Results:
- An international standard for teicoplanin was successfully established.
- The activity of the international standard teicoplanin was determined to be 51,550 IU per ampoule.
Conclusions:
- The established international standard provides a reliable reference for teicoplanin quantification.
- This standardization facilitates consistent quality and therapeutic efficacy of teicoplanin worldwide.