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Related Experiment Videos

[Fibronectin, aging and related pathologies].

J Labat-Robert1, X Chevalier

  • 1Laboratoire de Biologie du Tissu Conjonctif (URA 1460), Faculté de Médecine, Université Paris.

Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1991
PubMed
Summary
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Plasma and tissue fibronectin (FN) levels rise with age and certain diseases. Studying FN and its variants offers insights into aging and related health conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Gerontology

Context:

  • Fibronectin (FN) is a crucial extracellular matrix glycoprotein.
  • Age-related changes in FN levels and biosynthesis are increasingly recognized.
  • Specific diseases impact FN expression, suggesting a role in pathology.

Purpose:

  • To investigate the relationship between aging, diseases, and fibronectin (FN) levels.
  • To explore the influence of age, disease, nutrition, and UV light on FN biosynthesis and splicing.
  • To assess the potential of plasma and tissue FN as biomarkers for aging and associated pathologies.

Summary:

  • Plasma and tissue fibronectin (FN) concentrations increase with chronological aging.
  • Age-dependent diseases like diabetes, osteoarthritis, and Werner syndrome elevate tissue FN biosynthesis.

Related Experiment Videos

  • Plasma FN levels decrease in diabetes and breast cancer, while alternative splicing of the FN gene varies with age and disease.

    • Impact:

    • Determining plasma FN and its isoforms can aid in understanding chronological aging.
    • Studying tissue FN provides insights into age-related diseases and their mechanisms.
    • FN analysis may serve as a valuable tool for diagnosing and monitoring aging and related pathologies.