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[Matrix metalloproteinase (MMP)].

W Hornebeck1, C Lafuma

  • 1Laboratoire de Biologie du Tissu Conjonctif (URA CNRS 1460), Faculté de Médecine, Université Paris.

Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1991
PubMed
Summary
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Matrix metalloproteinases (MMPs) degrade extracellular matrix during aging and disease. Their activity is regulated by gene expression and activation processes, with tissue inhibitors of metalloproteinases (TIMPs) providing control.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Context:

  • Matrix metalloproteinases (MMPs) are crucial zinc-dependent enzymes involved in extracellular matrix (ECM) degradation.
  • These enzymes play significant roles in physiological and pathological processes, including tissue remodeling during aging.
  • MMPs are secreted as inactive zymogens by various cell types, necessitating activation for their function.

Purpose:

  • To elucidate the regulatory mechanisms governing matrix metalloproteinase (MMP) expression and activation.
  • To highlight the role of MMPs in extracellular matrix remodeling, particularly in the context of aging.
  • To describe the intricate control of MMP activity by endogenous inhibitors.

Summary:

  • Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases responsible for degrading extracellular matrix macromolecules.

Related Experiment Videos

  • MMP expression is regulated transcriptionally by diverse factors, including cytokines, chemicals, growth factors, and cellular aging.
  • Activation of MMP zymogens occurs via various agents, and their extracellular activity is tightly controlled by tissue inhibitors of metalloproteinases (TIMPs).

    • Impact:

    • Understanding MMP regulation provides insights into tissue remodeling in aging and disease.
    • This knowledge can inform therapeutic strategies targeting MMPs in conditions associated with abnormal ECM degradation.
    • Elucidating the balance between MMPs and TIMPs is critical for comprehending tissue homeostasis and pathology.