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Is antidepressant treatment associated with reduced cognitive decline in Alzheimer's disease?
Enrico Mossello1, Marta Boncinelli, Veronica Caleri
1Department of Critical Care Medicine and Surgery, Unit of Gerontology and Geriatric Medicine, University of Florence and Azienda Ospedaliero-Universitaria Careggi, Florence, Italy. enrico.mossello@unifi.it
Background:
Although antidepressant drugs (ATD) are frequently prescribed to patients with Alzheimer's disease (AD), their effect on cognitive status has been only rarely assessed.
Methods:
The impact of depressive symptoms and ATD on cognitive status was retrospectively assessed in 72 older AD outpatients with mild-to-moderate cognitive impairment, treated with cholinesterase inhibitors, over a 9-month follow-up.
Results:
Compared to subjects without baseline depressive symptoms, those with symptoms who were continuously treated with ATD had less cognitive decline; those never treated, or not continuously treated despite baseline symptoms, had an intermediate trend. Such a protective action of ATD was, at least in part, independent of their action on depressive symptoms.
Conclusion:
These observations suggest that ATD may reduce cognitive decline in depressed older AD patients.
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