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Updated: Aug 9, 2026

Real-time Cytotoxicity Assays in Human Whole Blood
Published on: November 7, 2014
Anti-CD3- or PHA-induced cytotoxicity in human intraepithelial and lamina propria lymphocytes
1Medizinische Universitätsklinik, Immunologisches Labor, Würzburg, BRD.
Abstract:
Morphological data in humans and rodents and functional data of intraepithelial lymphocytes of mice support the idea that cytotoxic cells are a significant population of the human mucosa. Previously it was shown that human IEL have no spontaneous cell-mediated cytotoxicity and that human LPL cells have anti-CD3-mediated cytotoxicity. We confirm that most individuals have anti-CD3- or PHA-mediated cytotoxicity of LPL. In IEL we do not find cytotoxic function in short-term assays. There is no difference between patients with colon cancer and inflammatory bowel disease.
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