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Updated: Jul 6, 2026
Isolation of Soluble and Insoluble PrP Oligomers in the Normal Human Brain
Published on: October 3, 2012
Intraventricular pentosan polysulphate in human prion diseases: an observational study in the UK
1Department of Medical and Cardiovascular Studies, Western Infirmary, Glasgow, UK. gcl136@clinmed.gla.ac.uk
Unlabelled:
BACKGROUND, PURPOSE AND METHODS: This observational study assessed the effect of continuous intraventricular infusion of pentosan polysulphate (PPS) in seven patients at different clinical centres in the UK.
Results:
Complications of intraventricular catheterization were frequent. PPS was well-tolerated over a wide dose range (11-110 microg/kg/day) during the 6-month study. Four patients were assessed for the entire study period: one remained stable, two showed minimal deterioration and one progressed significantly.
Conclusion:
Mean survival of all patients was longer than reported values for natural history of specific prion disorders. Possible reasons for these findings are explored.
