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Headache in primary Sjögren's syndrome: a prevalence study
F Gökçay1, G Oder, N Celebisoy
1Department of Neurology, Ege University Medical School, Bornova, Izmir, Turkey. figen.gokcay@ege.edu.tr
Acta Neurologica Scandinavica
|March 22, 2008
Summary
Headache, including migraine and tension-type, is highly prevalent in primary Sjögren's syndrome (pSS) patients. This increased prevalence may stem from the autoimmune disease activity, even without clear clinical or laboratory markers.
Area of Science:
- Rheumatology
- Neurology
- Immunology
Background:
- Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease.
- Headache is a common but understudied symptom in pSS patients.
Purpose of the Study:
- To determine the prevalence of headache in patients with pSS.
- To investigate the association between headache types and the clinical/serologic features of pSS.
Main Methods:
- A questionnaire based on International Headache Society criteria was used.
- 133 pSS patients and 97 healthy controls were included in the study.
Main Results:
- Headache was present in 104 out of 133 pSS patients.
- Migraine and tension-type headache were significantly more common in pSS patients than in controls (P < 0.001).
- No association was found between headache types and clinical or laboratory manifestations of pSS.
Conclusions:
- Headache, particularly migraine, is highly prevalent in pSS.
- The increased prevalence may be linked to immuno-mediated disease activity.
- This link may exist without obvious clinical or laboratory indicators.
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