Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Demand-controlled continuous spinal-cerebral morphine administration via an implanted programmable pump].

C Probst1

  • 1Neurochirurgische Klinik, Kantonsspital Aarau.

Schweizerische Rundschau Fur Medizin Praxis = Revue Suisse De Medecine Praxis
|November 12, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estimating the changing burden of disease attributable to alcohol use in South Africa for 2000, 2006 and 2012.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2022
Same author

PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma.

Molecular cancer·2022
Same author

Traumatic events and psychotic experiences: a nationally representative study in Thailand.

Epidemiology and psychiatric sciences·2021
Same author

Identification of Atoxigenic Aspergillus flavus Isolates to Reduce Aflatoxin Contamination of Maize in Kenya.

Plant disease·2019
Same author

Powdery Mildew Outbreaks caused by Podosphaera macularis on Hop Cultivars Possessing the Resistance Gene R6 in the Pacific Northwestern United States.

Plant disease·2019
Same author

A sensitive and specific assay for the serological diagnosis of antilaminin 332 mucous membrane pemphigoid.

The British journal of dermatology·2018

Demand-controlled spinal and cerebral morphine administration offers sustained pain relief with minimal side effects, even for severe, therapy-resistant pain. This method is also effective for deafferentation pain, potentially requiring higher doses.

Area of Science:

  • Neurology
  • Pain Management
  • Pharmacology

Background:

  • Advancements in programmable implanted pumps have increased the utility of demand-controlled spinal and cerebral morphine administration.
  • Continuous low-dose infusion provides a sustained pain-free state with minimized risks and side effects.

Observation:

  • This method is feasible for treating severe, therapy-resistant pain in benign conditions.
  • Neurostimulation and surgical interruption remain essential for specific pain types (deafferentation and nociceptive pain, respectively).

Findings:

  • The application of spinal and cerebral morphine is appropriate for deafferentation pain.
  • Higher morphine doses may be necessary for effective treatment of deafferentation pain.

Implications:

Related Experiment Videos

  • Demand-controlled morphine delivery represents a significant advancement in managing complex pain syndromes.
  • Re-evaluation of morphine's role in deafferentation pain management is warranted, challenging previous assumptions.