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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Regional Terms01:12

Regional Terms

Regional terms describe anatomy by dividing the body parts into different regions that contain structures involved in contributing similar functions. Using these terms helps increase the accurate description and identification of the particular region of interest or region affected by the disease.
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Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

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Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
06:59

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Published on: September 8, 2023

Regional migratory osteoporosis.

John G Cahir1, Andoni P Toms

  • 1Department of Radiology, Norfolk and Norwich University Hospital, Norfolk NR4 7UY, United Kingdom. john.cahir@nnuh.nhs.uk

European Journal of Radiology
|March 22, 2008
PubMed
Summary

Regional migratory osteoporosis (RMO) is an uncommon condition causing joint pain that moves through lower limb joints. It is likely under-diagnosed and may be related to transient osteoporosis of the hip.

Area of Science:

  • Orthopedics
  • Radiology
  • Rheumatology

Background:

  • Regional migratory osteoporosis (RMO) presents as migrating arthralgia in lower limb weight-bearing joints.
  • It predominantly affects men in their fifth and sixth decades, often with proximal to distal symptom spread.
  • The condition is likely under-diagnosed, with literature revealing 63 documented cases.

Purpose of the Study:

  • To describe the typical imaging findings of RMO.
  • To review the world literature on RMO and related conditions.
  • To discuss the relationship between RMO and transient osteoporosis of the hip (TOH).

Main Methods:

  • Review of world literature on regional osteoporosis and migratory bone marrow edema.
  • Description and illustration of imaging findings (radiographs, MRI, CT, bone scintigraphy).

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Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
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Published on: September 28, 2017

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Last Updated: Jul 6, 2026

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Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
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  • Comparison of RMO radiology with transient osteoporosis of the hip (TOH).

    • Main Results:

    • RMO imaging findings are indistinguishable from TOH, differing mainly in migratory symptoms.
    • 63 cases of regional osteoporosis or bone marrow edema with migratory symptoms were identified.
    • Systemic osteoporosis may be an accompanying feature, suggesting an underlying etiology.

    Conclusions:

    • RMO and TOH are likely part of the same disease spectrum.
    • The migratory nature of symptoms is key to differentiating RMO.
    • Further understanding of RMO's etiology and management is needed, considering systemic osteoporosis.