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Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection
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[Assisted procreation technology and people with HIV].

Juliette Guibert1, Marianne Leruez-Ville, Emmanuel Dulioust

  • 1Service de gynécologie-obstétrique II, Unité de médecine de la reproduction, AP-HP, Hôpital Cochin, 75014 Paris, France. juliette.guibert@cch.aphp.fr

Presse Medicale (Paris, France : 1983)
|March 22, 2008
PubMed
Summary

Assisted reproduction technologies (ART) are authorized for human immunodeficiency virus (HIV) positive individuals in France, enabling conception while preventing transmission. Strict health criteria ensure safety for both partners and potential offspring.

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Published on: September 5, 2016

Area of Science:

  • Reproductive Medicine
  • Infectious Diseases
  • Public Health Policy

Context:

  • France permits assisted reproduction technologies (ART) for human immunodeficiency virus (HIV) positive individuals via a 2001 ministerial decree.
  • ART aims to reduce HIV transmission risk between partners and address infertility in serodiscordant couples.
  • Specific clinical criteria, including CD4 T lymphocyte count and viral load stability, are mandatory for HIV patients undergoing ART.

Purpose:

  • To outline the regulatory framework and clinical guidelines for utilizing ART in HIV-positive individuals in France.
  • To detail the procedures for sperm preparation and selection to ensure HIV RNA negativity.
  • To inform about the management of pregnancy planning and antiretroviral treatment optimization for HIV-positive women undergoing ART.

Summary:

  • ART procedures are adapted based on fertility assessments and seminal viral load, with prepared spermatozoa validated as HIV RNA negative.
  • Antiretroviral therapy is not mandatory for ART but may be required if seminal viral load is high.
  • For HIV-positive women, counseling on transmission risks and antiretroviral toxicity is crucial, guiding treatment optimization, especially during the third trimester.

Impact:

  • Several thousand European couples have successfully used ART, with no reported HIV transmissions.
  • Approximately 50% of couples undergoing ART can achieve conception.
  • Informed decision-making regarding ART is supported, with about one-third declining the procedure after consultation.