Does radial use as a second arterial conduit for coronary artery bypass grafting improve long-term outcomes in

Thomas A Schwann1, Anoar Zacharias, Christopher J Riordan

  • 1Division of Cardiothoracic Surgery, The Regional Heart and Vascular Center at St. Vincent Mercy Medical Center, Toledo, OH 43608, USA.

Insights

For diabetic patients undergoing coronary artery bypass grafting (CABG), using a radial artery graft alongside an internal thoracic artery (ITA) graft did not improve survival compared to vein grafts. This suggests the radial artery’s benefits in CABG are mainly for non-diabetic individuals.

Area of Science:

  • Cardiovascular Surgery
  • Arterial Grafting
  • Diabetic Patient Outcomes

Background:

  • Multiple arterial grafts offer survival benefits in general coronary artery bypass grafting (CABG).
  • Conflicting data exists on the survival benefits of using two internal thoracic artery (ITA) grafts in diabetic patients.
  • The comparative survival of radial artery versus ITA as a second arterial conduit in diabetics remains unstudied.

Purpose of the Study:

  • To investigate the survival outcomes of using radial artery versus vein grafts as a second arterial conduit in diabetic CABG patients.
  • To compare the efficacy of ITA/radial grafts versus ITA/vein grafts in diabetic populations, stratified by insulin use.

Main Methods:

  • A retrospective analysis of 1516 diabetic primary isolated CABG patients with at least one ITA graft.
  • Patients were divided into ITA/radial (n=626) and ITA/vein (n=890) groups.
  • One-to-one propensity score matching created comparable cohorts of 475 ITA/radial and 475 ITA/vein patients, including insulin-dependent and non-insulin-dependent subgroups.

Main Results:

  • Unadjusted survival rates at 1, 5, and 10 years were higher for the ITA/radial group compared to the ITA/vein group (p<0.0001).
  • Similarly, non-insulin-dependent diabetics showed better unadjusted survival than insulin-dependent diabetics (p<0.0001).
  • In propensity-matched patients, 11-year Kaplan-Meier analysis revealed no significant difference in survival between ITA/radial and ITA/vein groups for all diabetics combined (p=0.53) or the non-insulin-dependent cohort (p=0.76).

Conclusions:

  • Utilizing a radial artery as the second arterial conduit in diabetic CABG patients does not confer a survival advantage over vein grafts.
  • Potential reasons for this finding include diminished radial graft patency and increased vasoreactivity in diabetics.
  • The survival benefit of radial artery grafts in CABG appears to be primarily in non-diabetic patients.
Abstract

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