Does radial use as a second arterial conduit for coronary artery bypass grafting improve long-term outcomes in diabetics?
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Published on: September 20, 2020
Thomas A Schwann1, Anoar Zacharias, Christopher J Riordan
1Division of Cardiothoracic Surgery, The Regional Heart and Vascular Center at St. Vincent Mercy Medical Center, Toledo, OH 43608, USA.
Insights
For diabetic patients undergoing coronary artery bypass grafting (CABG), using a radial artery graft alongside an internal thoracic artery (ITA) graft did not improve survival compared to vein grafts. This suggests the radial artery’s benefits in CABG are mainly for non-diabetic individuals.
Area of Science:
- Cardiovascular Surgery
- Arterial Grafting
- Diabetic Patient Outcomes
Background:
- Multiple arterial grafts offer survival benefits in general coronary artery bypass grafting (CABG).
- Conflicting data exists on the survival benefits of using two internal thoracic artery (ITA) grafts in diabetic patients.
- The comparative survival of radial artery versus ITA as a second arterial conduit in diabetics remains unstudied.
Purpose of the Study:
- To investigate the survival outcomes of using radial artery versus vein grafts as a second arterial conduit in diabetic CABG patients.
- To compare the efficacy of ITA/radial grafts versus ITA/vein grafts in diabetic populations, stratified by insulin use.
Main Methods:
- A retrospective analysis of 1516 diabetic primary isolated CABG patients with at least one ITA graft.
- Patients were divided into ITA/radial (n=626) and ITA/vein (n=890) groups.
- One-to-one propensity score matching created comparable cohorts of 475 ITA/radial and 475 ITA/vein patients, including insulin-dependent and non-insulin-dependent subgroups.
Main Results:
- Unadjusted survival rates at 1, 5, and 10 years were higher for the ITA/radial group compared to the ITA/vein group (p<0.0001).
- Similarly, non-insulin-dependent diabetics showed better unadjusted survival than insulin-dependent diabetics (p<0.0001).
- In propensity-matched patients, 11-year Kaplan-Meier analysis revealed no significant difference in survival between ITA/radial and ITA/vein groups for all diabetics combined (p=0.53) or the non-insulin-dependent cohort (p=0.76).
Conclusions:
- Utilizing a radial artery as the second arterial conduit in diabetic CABG patients does not confer a survival advantage over vein grafts.
- Potential reasons for this finding include diminished radial graft patency and increased vasoreactivity in diabetics.
- The survival benefit of radial artery grafts in CABG appears to be primarily in non-diabetic patients.
Objectives:
The evidence supporting the survival benefit of multiple arterial grafts in the general coronary bypass surgery (CABG) population is compelling. Alternatively, results of studies comparing 2 versus 1 internal thoracic artery (ITA) grafts in diabetics have reported conflicting survival data. The use of radial versus ITA as the second arterial conduit has not been studied.
Methods:
We obtained complete death follow-up in 1516 consecutive diabetic [64+/-10 years (mean+/-SD). Insulin/no insulin: There were 540 (36%)/976 (64%)] primary isolated CABG patients all with >or=1 ITA grafts. The series included 626 ITA/radial (41%) and 890 ITA/vein (59%) patients. Using separate radial-use propensity models, we matched one-to-one 475 (76%) ITA/radial to 475 (53%) unique ITA/vein patients; each including 166 insulin and 309 no insulin patients.
Results:
Unadjusted survival was markedly better for (1) ITA/radial (94.3%, 86.7% and 70.4% at 1, 5 and 10 years, respectively) versus ITA/vein (91.8%, 74.5% and 53.8%; p<0.0001) and (2) for no insulin (94.2%, 82.8% and 65.5%) versus insulin (90.4%, 73.1% and 49.2%; p<0.0001). In matched patients, 11-year Kaplan-Meier analysis showed essentially identical ITA/radial and ITA/vein survival for all diabetics combined (p=0.53; log rank) and for the no insulin (p=0.76) cohort. Lastly, a trend for better ITA/radial survival in insulin dependent diabetics after the second postoperative year did not reach significance (p=0.13).
Conclusions:
Using radial as a second arterial conduit as opposed to vein grafting did not confer a survival benefit in diabetics. This unexpected result is perhaps related to relatively diminished radial graft patency and/or the augmented radial vasoreactivity characteristic of diabetics. These findings indicate that the radial survival advantage demonstrated in the general CABG population lies primarily in non-diabetics in whom this advantage may be underestimated.
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