Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Do hepatic and biliary functional data from gadoxetate-enhanced MRI add value in predicting outcomes in primary sclerosing cholangitis (PSC)?

European radiology·2026
Same author

The role of MRCP in characterizing ductal communication and high-risk features in pancreatic cystic lesions.

Abdominal radiology (New York)·2026
Same author

Solid masses arising in transplanted kidneys.

Abdominal radiology (New York)·2025
Same author

Radiologic evaluation of abdominal compartment syndrome: an updated educational review.

Abdominal radiology (New York)·2025
Same author

Serous borderline ovarian tumor and low-grade serous ovarian cancer.

Abdominal radiology (New York)·2025
Same author

Imaging findings of gastric glomus tumors.

Abdominal radiology (New York)·2024

Related Experiment Video

Updated: Jul 6, 2026

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

Nonalcoholic fatty liver disease.

Chandana G Lall1, Alex M Aisen, Navin Bansal

  • 1Department of Radiology, Indiana University School of Medicine, 550 N University Blvd., Ste. UH 0279, Indianapolis, IN 46202, USA.

AJR. American Journal of Roentgenology
|March 22, 2008
PubMed
Summary

Nonalcoholic steatohepatitis (NASH) is a growing cause of chronic liver disease. This review covers NASH epidemiology, pathogenesis, and diagnostic approaches, including advanced imaging techniques for liver fat, inflammation, and fibrosis.

More Related Videos

In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease
07:03

In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease

Published on: July 19, 2024

Related Experiment Videos

Last Updated: Jul 6, 2026

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease
07:03

In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease

Published on: July 19, 2024

Area of Science:

  • Hepatology
  • Radiology
  • Gastroenterology

Background:

  • Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver conditions.
  • Nonalcoholic steatohepatitis (NASH), an inflammatory subtype of NAFLD, is increasingly prevalent.
  • NASH is a significant driver of advanced chronic liver disease and liver failure.

Purpose of the Study:

  • To review the epidemiology of NAFLD and NASH.
  • To discuss the pathogenesis of NAFLD and NASH.
  • To outline the clinical and radiologic diagnostic methods for NAFLD subtypes.

Main Methods:

  • Literature review of epidemiological data.
  • Synthesis of current understanding of NAFLD/NASH pathogenesis.
  • Overview of established and emerging diagnostic imaging modalities.

Main Results:

  • NAFLD prevalence is rising globally, with NASH representing a critical stage.
  • Pathogenesis involves a complex interplay of metabolic, genetic, and environmental factors.
  • Diagnosis relies on clinical assessment, laboratory tests, and increasingly sophisticated imaging.

Conclusions:

  • Understanding NAFLD/NASH epidemiology and pathogenesis is crucial for public health.
  • Accurate diagnosis, including differentiating simple steatosis from NASH, is essential for patient management.
  • Evolving imaging techniques offer promising non-invasive methods to assess liver fat, inflammation, and fibrosis.