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04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Nephrogenic systemic fibrosis: possible association with a predisposing infection
Lauren Parks Golding1, James M Provenzale
1Department of Internal Medicine, Moses H. Cone Hospital, Greensboro, NC, USA.
AJR. American Journal of Roentgenology
|March 22, 2008
Summary
Infection during Magnetic Resonance (MR) contrast administration significantly increases the risk of nephrogenic systemic fibrosis (NSF) in patients with renal failure. This study confirms a strong association between infection and NSF development.
Area of Science:
- Nephrology
- Radiology
- Infectious Diseases
Background:
- Nephrogenic Systemic Fibrosis (NSF) is a debilitating condition linked to gadolinium-based contrast agents in patients with renal failure.
- Previous reports suggest infection at the time of contrast administration may increase NSF risk.
Purpose of the Study:
- To assess the frequency of infection in patients who developed NSF after receiving MR contrast agents.
- To determine the association between infection and NSF development in renal failure patients.
Main Methods:
- Retrospective analysis of 8 NSF patients between 2002-2006, focusing on those who received gadodiamide.
- Extrapolation of data to estimate NSF rates in infected versus uninfected renal failure patients.
- Statistical analysis using Fisher's exact test and odds ratios to determine the association between infection and NSF.
Main Results:
- Five of seven NSF patients receiving MR contrast had concurrent infections.
- NSF rate was significantly higher in infected (6.7%) compared to uninfected (0.26%) renal failure patients.
- A strong association was found between infection and NSF (Odds Ratio: 25, p < 0.001).
Conclusions:
- Infection at the time of MR contrast administration is a significant risk factor for NSF in renal failure patients.
- The findings support the hypothesis that infection potentiates NSF development in this vulnerable population.
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