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Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
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Published on: May 30, 2011

Arterial spin-labeling in routine clinical practice, part 3: hyperperfusion patterns.

A R Deibler1, J M Pollock, R A Kraft

  • 1Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

AJNR. American Journal of Neuroradiology
|March 22, 2008
PubMed
Summary

Arterial spin-labeled (ASL) perfusion imaging effectively detects brain hyperperfusion in various diseases. This technique visualizes focal, regional, and global increases in blood flow, aiding in diagnosing conditions that may be missed by conventional MRI.

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Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling

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Area of Science:

  • Neuroimaging
  • Radiology
  • Cerebrovascular Imaging

Background:

  • Arterial spin-labeled (ASL) perfusion imaging is a valuable tool in clinical neuroimaging.
  • It accurately demonstrates alterations in brain perfusion, including hyperperfusion patterns.
  • The underlying causes of hyperperfusion detected by ASL have not been fully characterized.

Purpose of the Study:

  • To characterize the causes of focal, regional, and global hyperperfusion observed in clinical ASL studies.
  • To highlight the utility of ASL in depicting various disease processes associated with increased cerebral blood flow.
  • To compare the detection capabilities of ASL with conventional MRI for hyperperfusion states.

Main Methods:

  • Implementation of ASL perfusion imaging into routine clinical neuroimaging protocols.
  • Observation and analysis of hyperperfusion patterns (focal, regional, global) across diverse disease processes.
  • Correlation of ASL findings with clinical diagnoses and conventional MRI findings.

Main Results:

  • ASL successfully depicts focal hyperperfusion in lesions like brain tumors and vascular malformations.
  • Global hyperperfusion causes (e.g., postanoxia vasodilation, hypercapnia) may be missed by conventional MRI but are detectable by ASL.
  • Regional hyperperfusion, seen in reversible encephalopathies and luxury perfusion, is consistently illustrated on ASL cerebral blood flow maps.

Conclusions:

  • ASL perfusion imaging is a robust technique for routine clinical neuroimaging, capable of identifying diverse hyperperfusion states.
  • ASL offers superior detection of certain global and regional hyperperfusion phenomena compared to conventional MRI.
  • Characterizing the causes of hyperperfusion with ASL aids in the diagnosis and management of various neurological conditions.