Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Steroidal fatty acid esters.

R B Hochberg1, S L Pahuja, J E Zielinski

  • 1Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510.

The Journal of Steroid Biochemistry and Molecular Biology
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Equivalence of cell survival data for radiation dose and thermal dose in ablative treatments: analysis applied to essential tremor thalamotomy by focused ultrasound and gamma knife.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·2017
Same author

Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells.

Oncogene·2012
Same author

Optic neuropathy in patients with glioblastoma receiving bevacizumab.

Neurology·2009
Same author

Disruption of spermatogenesis and Sertoli cell structure and function by the indenopyridine CDB-4022 in rats.

Biology of reproduction·2001
Same author

Estradiol-16alpha-carboxylic acid esters as locally active estrogens.

Journal of medicinal chemistry·2001
Same author

[7alpha-18F]fluoro-17alpha-methyl-5alpha-dihydrotestosterone: a ligand for androgen receptor-mediated imaging of prostate cancer.

Nuclear medicine and biology·2001

Steroidal fatty acid esters, including estrogen and glucocorticoid forms, are newly discovered metabolites. Estrogen esters act as long-lived, potent hormones, while glucocorticoid esters have rapid activity, suggesting diverse physiological roles.

Area of Science:

  • Endocrinology
  • Steroid biochemistry
  • Metabolomics

Background:

  • Steroidal fatty acid esters are an unexpected class of metabolites.
  • These non-polar esters, including those of pregnenolone and dehydroisoandrosterone, are found in adrenal tissue, blood, brain, and ovaries.
  • Most steroid hormone families are now known to exist in esterified forms.

Purpose of the Study:

  • To investigate the distinct enzymatic esterification of estrogens and glucocorticoids.
  • To analyze the fatty acid composition and biological activity of steroidal esters.
  • To elucidate the physiological roles of steroidal fatty acid esters.

Main Methods:

  • Biosynthetic experiments comparing estradiol and corticosterone esterification.
  • Analysis of fatty acid composition in steroidal esters.

Related Experiment Videos

  • Assessment of biological activity and tissue distribution of steroidal esters.

    • Main Results:

    • Estrogen and glucocorticoid families are esterified by separate enzymes.
    • Estradiol esters exhibit heterogeneous fatty acid composition and prolonged, potent estrogenic activity, acting as a hormonal reservoir.
    • Glucocorticoid (corticosterone) esters show rapid hydrolysis and activity similar to the free steroid, mediated by a labile C-21 ester.

    Conclusions:

    • Estrogen fatty acid esters serve as long-lived, potent hormones, analogous to pharmacological preparations.
    • Glucocorticoid esters have rapid biological activity due to labile ester linkages.
    • The precise physiological functions of various steroidal esters, beyond prolonged hormonal activity, remain to be fully elucidated, suggesting broader biological roles.