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Effects of bestatin (Ubenimex) on human T-cell colony formation
Y Wakabayashi1, M Hashimoto, K Saitoh
1Department of Internal Medicine, Juntendo University, School of Medicine, Tokyo, Japan.
Anti-Cancer Drugs
|February 1, 1991
Abstract:
The antitumor action of bestatin is considered to be an indirect action mediated by T-cells. Therefore, we investigated the effects of bestatin on the differentiation and proliferation of human precursor T-cells using a colony formation technique. Bestatin did not increase the overall number of T-cell colonies, but it significantly increased in CD4+ cell and significantly decreased in CD8+ cell subpopulations. It also induced CD4+.8+ cells. These findings indicated that bestatin acts on precursor T-cells to induce the differentiation of these cells into CD4+ cells.