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Updated: Jul 6, 2026
06:15
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Conjunctival squamous cell carcinoma in the anophthalmic socket
John Nguyen1, Doina Ivan, Bita Esmaeli
1Section of Ophthalmology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Ophthalmic Plastic and Reconstructive Surgery
|March 22, 2008
Summary
Squamous cell carcinoma (SCC) can develop in the anophthalmic socket years after eye removal and prosthesis use. Regular socket inspection is crucial for early detection of conjunctival SCC.
Area of Science:
- Ophthalmology
- Oncology
Background:
- Anophthalmic sockets, post-enucleation, are typically considered inert.
- Chronic ocular prosthesis wear is common in anophthalmic patients.
Observation:
- Two patients developed conjunctival squamous cell carcinoma (SCC) over 44 years after enucleation and prosthesis use.
- Neither patient had typical risk factors for SCC, such as UV exposure, HIV, or immune compromise.
Findings:
- Conjunctival SCC can arise in the anophthalmic socket long after enucleation.
- The development of SCC in this context may occur without predisposing factors.
Implications:
- Routine ophthalmological examination of an anophthalmic socket with a prosthesis is essential.
- Early detection of conjunctival SCC in these patients is critical for management and prognosis.
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