Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
Transgenic Organisms00:53

Transgenic Organisms

Overview
Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Bringing safe and effective therapies to premenopausal women with breast cancer: efforts to broaden eligibility criteria": [Annals of Oncology 32 (2021) 950-953].

Annals of oncology : official journal of the European Society for Medical Oncology·2022
Same author

Bringing safe and effective therapies to premenopausal women with breast cancer: efforts to broaden eligibility criteria.

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

Alternative rib bone biopsy measurements to estimate changes in skeletal mineral reserves in cattle.

Animal : an international journal of animal bioscience·2018
Same author

Evaluating surface erythropoietin receptor in multiple myeloma.

Leukemia·2012
Same author

A Note on the Agglutination of Meningococcus.

The Yale journal of biology and medicine·2011
Same author

Studies on the Action of Crude Penicillin.

Transactions of the American Clinical and Climatological Association·2011
Same journal

Improving the precision of AAV lung gene therapy for SP-B deficiency using computationally derived lung-specific promoters.

Gene therapy·2026
Same journal

Recent advancements in improving cross-species applicability of bioengineered AAV capsids.

Gene therapy·2026
Same journal

Assessment of F/HN-pseudotyped lentiviral vector following intravenous delivery to mice.

Gene therapy·2026
Same journal

Applications of genome editing technologies in the treatment of human diseases.

Gene therapy·2026
Same journal

High resolution ES-DMA quantifies AAV capsid DNA content by electrical mobility to mass correlation.

Gene therapy·2026
Same journal

AAV8-mediated mouse/human PROC expression rescues thrombophilia in hereditary protein C-deficient mice.

Gene therapy·2026
See all related articles

Related Experiment Video

Updated: Jul 6, 2026

Regioselective Biolistic Targeting in Organotypic Brain Slices Using a Modified Gene Gun
06:40

Regioselective Biolistic Targeting in Organotypic Brain Slices Using a Modified Gene Gun

Published on: October 24, 2014

Using gene transfer to circumvent off-target effects.

C P Miller1, C A Blau

  • 1Department of Medicine/Hematology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA.

Gene Therapy
|March 22, 2008
PubMed
Summary
This summary is machine-generated.

This study introduces a novel method to control cell signaling, overcoming issues with growth factors in gene and cell therapy. The approach uses conditionally active proteins activated by synthetic ligands to prevent unwanted side effects.

More Related Videos

In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium
10:18

In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium

Published on: May 6, 2018

Transfection, Selection, and Colony-picking of Human Induced Pluripotent Stem Cells TALEN-targeted with a GFP Gene into the AAVS1 Safe Harbor
07:28

Transfection, Selection, and Colony-picking of Human Induced Pluripotent Stem Cells TALEN-targeted with a GFP Gene into the AAVS1 Safe Harbor

Published on: February 1, 2015

Related Experiment Videos

Last Updated: Jul 6, 2026

Regioselective Biolistic Targeting in Organotypic Brain Slices Using a Modified Gene Gun
06:40

Regioselective Biolistic Targeting in Organotypic Brain Slices Using a Modified Gene Gun

Published on: October 24, 2014

In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium
10:18

In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium

Published on: May 6, 2018

Transfection, Selection, and Colony-picking of Human Induced Pluripotent Stem Cells TALEN-targeted with a GFP Gene into the AAVS1 Safe Harbor
07:28

Transfection, Selection, and Colony-picking of Human Induced Pluripotent Stem Cells TALEN-targeted with a GFP Gene into the AAVS1 Safe Harbor

Published on: February 1, 2015

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Cell Therapy

Background:

  • Recombinant growth factors often fail in clinical trials due to significant off-target effects.
  • Developing targeted therapeutic strategies is crucial for advancing gene and cell therapies.

Purpose of the Study:

  • To present a novel method for circumventing off-target effects in cellular therapies.
  • To enable precise control over cellular signaling pathways.

Main Methods:

  • Equipping cells with a conditionally active signaling protein.
  • Utilizing an exogenously administered synthetic ligand for specific protein activation.

Main Results:

  • Demonstrated a method to specifically activate cellular signaling.
  • Successfully circumvented the problem of off-target effects associated with traditional growth factors.

Conclusions:

  • This approach offers a promising strategy for enhancing the safety and efficacy of gene and cell therapies.
  • The conditional activation system has broad potential applications in various therapeutic contexts.