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Activity of vancomycin and teicoplanin against human polymorphonuclear leucocytes: a comparative study
F J Morán1, L F Puente, C Pérez-Giraldo
1Department of Microbiology, Faculty of Medicine, Badajoz, Spain.
The Journal of Antimicrobial Chemotherapy
|September 1, 1991
Summary
Teicoplanin and vancomycin, antibiotics, impact human immune cell function. Teicoplanin showed potential benefits for polymorphonuclear leukocytes (PMNs) in vitro, while vancomycin demonstrated some inhibitory effects.
Area of Science:
- Immunology
- Pharmacology
Background:
- Human polymorphonuclear leukocytes (PMNs) are crucial for innate immunity.
- Teicoplanin and vancomycin are glycopeptide antibiotics used to treat bacterial infections.
Purpose of the Study:
- To investigate the in vitro effects of therapeutic concentrations of teicoplanin and vancomycin on human PMN functions.
- To assess the impact of these antibiotics on PMN adherence, mobility, chemotaxis, phagocytosis, and candidacidal capacity.
Main Methods:
- In vitro study design.
- Evaluation of PMN adherence, spontaneous mobility, chemotaxis, phagocytic, and candidacidal activity.
- Incubation with various concentrations of teicoplanin and vancomycin.
Main Results:
- Teicoplanin did not affect PMN adherence but showed a significant increase in spontaneous mobility at 50 mg/L.
- Vancomycin showed a non-significant decrease in adherence and a significant reduction in chemotaxis at 1 and 50 mg/L.
- Teicoplanin demonstrated a favorable, though not statistically significant, effect on PMN phagocytic and candidacidal capacity against Candida albicans.
Conclusions:
- Teicoplanin may positively influence certain human PMN functions in vitro.
- Vancomycin may impair PMN chemotaxis and adherence in a dose-dependent manner.
- Further research is warranted to elucidate the clinical implications of these in vitro findings.