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Updated: Jul 6, 2026
07:46
Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
Published on: May 9, 2013
[Ischemic preconditioning of the heart]
Alon Eisen1, Ehud Schwammenthal, Yehuda Adler
1Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel.
Harefuah
|March 25, 2008
Summary
Ischemic preconditioning, a protective response to brief ischemia, improves heart function and reduces damage. Understanding its mechanisms, particularly late preconditioning, could lead to new cardiovascular disease therapies.
Area of Science:
- Cardiology
- Physiology
Context:
- Ischemic preconditioning is a well-documented phenomenon observed in both animal and human hearts.
- It involves a brief period of ischemia that confers protection against subsequent prolonged ischemia.
- Both early and delayed (late) forms of preconditioning have been identified, with distinct mechanisms.
Purpose:
- To explore the mechanisms underlying ischemic preconditioning, with a focus on the late phase.
- To highlight the potential for developing preconditioning mimetic agents.
- To investigate the therapeutic and preventive applications of preconditioning in cardiovascular diseases.
Summary:
- Ischemic preconditioning involves a short ischemic event that protects the myocardium from subsequent prolonged ischemia, improving function and reducing infarct size.
- The phenomenon is observed in various species and settings, including in vitro and in vivo human heart studies.
- Late preconditioning has a distinct and well-described mechanism compared to early preconditioning.
Impact:
- Unraveling the mechanisms of ischemic preconditioning could pave the way for novel therapeutic strategies.
- Development of preconditioning mimetic agents offers potential for treating and preventing cardiovascular diseases.
- This research holds promise for advancing cardiovascular medicine and patient outcomes.
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