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Updated: Jul 6, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
[Preparation of tablets containing enteric-coated diclofenac sodium pellets]
Xiao-Le Qi1, Jia-Bi Zhu, Sheng-Jun Chen
1Pharmaceutical Research Institute, China Pharmaceutical University, Nanjing 210038, China.
Abstract:
Fluidized-bed manufactured enteric-coated diclofenac sodium pellets were compressed into tablets. The blend of two aqueous acrylic resins dispersion in different ratios, Eudragit NE30D and Eudragit L30D-55, were used to prepare enteric-coated diclofenac sodium pellets of different particle sizes and coating level. The cushioning pellets with different properties and these enteric-coated pellets were compressed into tablets in different proportions. The drug release of the tablets containing these pellets would be lower than 10% in 2 h in simulated gastric fluid, but reach (83 +/- 2.42)% in 1 h in simulated enteric fluid. The mixture of Eudragit NE30D and Eudragit L30D-55 could be used to prepare enteric pellets which are suitable for compression. The cushioning pellets which were composed of stearic acid/microcrystalline cellulose (4:1, w/w) could avoid rupture of the coating of pellets during the compression.
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