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Published on: December 29, 2015
CVB translation: lessons from the polioviruses.
1Department of Molecualr Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
Current Topics in Microbiology and Immunology
|March 25, 2008
Summary
Coxsackievirus and poliovirus gene expression relies on translation control. This review details how viruses manipulate host translation, impacting viral replication and disease.
Area of Science:
- Virology
- Molecular Biology
- Biochemistry
Background:
- Coxsackievirus translation and replication research benefits from poliovirus studies.
- Enteroviruses control gene expression at the translation level.
- Viral infection alters host mRNA access to protein synthesis machinery.
Purpose of the Study:
- To review advances in enterovirus translational control.
- To compare coxsackievirus translational mechanisms with poliovirus.
- To explore the translational basis of viral phenotypes.
Main Methods:
- Literature review of poliovirus and coxsackievirus research.
- Analysis of viral modification of translation factors.
- Examination of internal ribosome entry site (IRES) function.
Main Results:
- Viral translation is largely controlled by internal ribosome entry sites (IRES).
- Viruses modify host translation factors to shut off host protein synthesis and promote viral translation.
- Differences in translational control contribute to coxsackievirus tissue specificity and neurovirulence.
Conclusions:
- Translational control is a key mechanism for enterovirus replication and pathogenesis.
- Understanding viral translation offers insights into host-pathogen interactions.
- Further research into coxsackievirus-specific translational strategies is warranted.
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