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Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
06:03

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

Published on: July 15, 2019

Pediatric group B coxsackievirus infections

J R Romero1

  • 1University of Nebraska Medical Center, 986495 Nebraska Medical, Omaha, NE 68198-6495, USA. jrromero@unmc.edu

Current Topics in Microbiology and Immunology
|March 25, 2008
PubMed

Insights

Coxsackievirus (CVB) infections are common in children, spreading mainly through the fecal-oral route but also from mother to infant. This review covers clinically relevant CVB syndromes, diagnosis, treatment, and prevention strategies.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Public Health

Background:

  • Enteroviruses, specifically Coxsackievirus (CVB), are significant pathogens in infants and children.
  • CVB infections pose a considerable health burden on pediatric populations worldwide.
  • Understanding transmission routes is crucial for effective control.

Purpose of the Study:

  • To review common and clinically relevant Coxsackievirus (CVB) related syndromes in children.
  • To provide an overview of diagnostic methods for CVB infections.
  • To discuss current treatment and prevention strategies for CVB.

Main Methods:

  • Literature review of existing studies on Coxsackievirus (CVB).
  • Focus on clinically relevant syndromes, diagnosis, treatment, and prevention.
  • Synthesis of information on transmission routes, including fecal-oral and vertical transmission.

Main Results:

  • CVB are established pediatric pathogens with diverse clinical manifestations.
  • Fecal-oral transmission is the primary route, but vertical transmission also occurs.
  • Effective diagnosis, treatment, and prevention are essential for managing CVB infections.

Conclusions:

  • Coxsackievirus (CVB) infections require comprehensive management strategies in pediatric care.
  • Continued research into diagnosis, treatment, and prevention is vital.
  • Public health efforts should focus on interrupting transmission routes.

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