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Related Concept Videos

Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Vagina01:26

Vagina

The vaginal canal is a tubular structure averaging about 10 cm in length that acts as the entryway to the female reproductive system and the passageway for menstrual flow and childbirth. The interior walls of the vagina exhibit concentric folds called rugae and are topped by an area known as the fornix, which connects with the protruding cervical portion of the uterus. This canal is comprised of an external fibrous layer, a muscular middle layer, and an inner lining with mucosal rugae, which...
Trichomoniasis01:18

Trichomoniasis

Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Related Experiment Video

Updated: Jul 6, 2026

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis
07:57

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis

Published on: December 8, 2011

Desquamative inflammatory vaginitis: what is it?

Ruth Murphy1, Libby Edwards

  • 1Department of Dermatology, Queens Medical Centre, Nottingham, UK. ruthmurphy1@aol.com

The Journal of Reproductive Medicine
|March 25, 2008
PubMed
Summary

This study identified two inflammatory patterns in desquamative inflammatory vaginitis, suggesting a need to explore an idiopathic subset. Treatment with clindamycin and clobetasone propionate showed effectiveness.

Area of Science:

  • Gynecologic pathology
  • Vaginal inflammation research

Background:

  • Desquamative inflammatory vaginitis (DIV) presents with significant symptoms like dyspareunia and increased discharge.
  • Understanding the underlying inflammatory processes in DIV is crucial for effective management.

Purpose of the Study:

  • To document the distinct inflammatory patterns observed in cases of desquamative inflammatory vaginitis.
  • To investigate the potential existence of an idiopathic subgroup within desquamative inflammatory vaginitis.

Main Methods:

  • A retrospective case note review was conducted.
  • Data from 11 women presenting with symptoms of painful sexual intercourse and increased vaginal discharge over 12 months were analyzed.

Main Results:

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Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis
07:57

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis

Published on: December 8, 2011

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  • Vulvar examination findings were typically normal or showed mild erythema and thin purulent discharge.
  • Vaginal wall examination revealed erythema indicative of inflammation.
  • Vaginal wall biopsies demonstrated two primary inflammatory patterns: lichenoid or nonspecific mixed inflammatory infiltrate.
  • Therapeutic intervention with clindamycin and clobetasone propionate yielded largely effective outcomes.

    • Conclusions:

    • The histological findings in desquamative inflammatory vaginitis require further elucidation.
    • Further research is warranted to determine if an idiopathic subset of desquamative inflammatory vaginitis exists or if the condition represents erosive lichen planus.