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Vitamin D endocrinology.

H F DeLuca

    Annals of Internal Medicine
    |September 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    This review details vitamin D metabolism, highlighting 1,25-dihydroxyvitamin D3 as a key calcium-regulating hormone. Disruptions in this pathway lead to metabolic bone diseases, which can be managed with vitamin D analogs.

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    Short-term regulation of the renal vitamin D receptor in rats by 1,25-dihydroxycholecalciferol is calcium insensitive.

    The Journal of nutrition·1992
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    Baculovirus-mediated expression of retinoic acid receptor type gamma in cultured insect cells reveals a difference in specific DNA-binding behavior with the 1,25-dihydroxyvitamin D3 receptor.

    Proceedings of the National Academy of Sciences of the United States of America·1992
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    Up-regulation of the vitamin D receptor in response to 1,25-dihydroxyvitamin D3 results from ligand-induced stabilization.

    The Journal of biological chemistry·1992
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    New concepts of vitamin D functions.

    Annals of the New York Academy of Sciences·1992
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    Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3.

    Proceedings of the National Academy of Sciences of the United States of America·1992
    Same author

    A new, highly sensitive assay for 1,25-dihydroxyvitamin D not requiring high-performance liquid chromatography: application of monoclonal antibody against vitamin D receptor to radioreceptor assay.

    Analytical biochemistry·1992

    Area of Science:

    • Endocrinology
    • Metabolism
    • Bone Biology

    Background:

    • Vitamin D is crucial for calcium and phosphate homeostasis.
    • Its metabolism involves hepatic and renal conversion into active forms.
    • Imbalances in vitamin D metabolism are linked to bone disorders.

    Purpose of the Study:

    • To review the current understanding of vitamin D metabolism.
    • To explore the role of vitamin D in metabolic bone disease.
    • To discuss therapeutic applications of vitamin D analogs.

    Main Methods:

    • Review of existing literature on vitamin D metabolism.
    • Analysis of regulatory mechanisms involving calcium, parathyroid hormone, and phosphorus.
    • Discussion of clinical implications and treatment strategies.

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    Main Results:

    • Detailed pathway of vitamin D3 to 25-hydroxyvitamin D3 (liver) and subsequently to 1,25-dihydroxyvitamin D3 or 24,25-dihydroxyvitamin D3 (kidneys).
    • 1,25-dihydroxyvitamin D3 identified as a critical calcium- and phosphate-mobilizing hormone.
    • Disruptions identified as causes for renal osteodystrophy, hypoparathyroidism, and vitamin D-dependency rickets.

    Conclusions:

    • Vitamin D metabolism is tightly regulated by vitamin D status, calcium, and phosphorus levels.
    • 1,25-dihydroxyvitamin D3 is a vital hormone for calcium regulation.
    • Synthetic analogs of 1,25-dihydroxyvitamin D3 offer therapeutic potential for bone and calcium disorders.