Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
ATP Synthase: Mechanism01:48

ATP Synthase: Mechanism

In animals, the mitochondrial F1F0 ATP synthase is the key protein that synthesizes ATP molecules through a complex catalytic mechanism. While the nuclear genome encodes the majority of ATP synthase subunits, the mitochondrial genome encodes some of the enzyme's most critical components. The formation of this multi-subunit enzyme is a complex multi-step process regulated at the level of transcription, translation, and assembly. Defects in one or more of these steps can result in decreased ATP...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nonspecific lower back pain in overhead athletes is multifactorial and is not solely determined by the type and intensity of the sport.

South African journal of sports medicine·2026
Same author

The spectrum of developmental and epileptic encephalopathies and their genetic heterogeneity are much broader than previously thought.

The Medical journal of Malaysia·2026
Same author

Bilateral hack sign not necessarily implies paraparesis.

Neurologia·2025
Same author

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios can only predict the severity of COVID-19 if the criteria for a biomarker are met.

The Medical journal of Malaysia·2025
Same author

The spectrum of ophthalmologic abnormalities in MELAS is broader than expected.

Archivos de la Sociedad Espanola de Oftalmologia·2025
Same author

In Patients not Suitable for Generalised Anaesthesia, Surgery for Necrotising Fasciitis under Spinal Anaesthesia should be Considered.

Malaysian orthopaedic journal·2025

Related Experiment Video

Updated: Jul 6, 2026

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

Is atherosclerosis a mitochondrial disorder?

J Finsterer1

  • 1Krankenanstalt Rudolfstiftung, Vienna, Austria. fifigs1@yahoo.de

VASA. Zeitschrift Fur Gefasskrankheiten
|March 25, 2008
PubMed
Summary
This summary is machine-generated.

Oxidative stress significantly contributes to atherosclerosis by damaging vascular cells and mitochondria. While current treatments are limited, experimental therapies targeting redox balance show promise in combating this complex disease.

More Related Videos

Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy
07:47

Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy

Published on: July 9, 2016

Using Live Cell STED Imaging to Visualize Mitochondrial Inner Membrane Ultrastructure in Neuronal Cell Models
08:48

Using Live Cell STED Imaging to Visualize Mitochondrial Inner Membrane Ultrastructure in Neuronal Cell Models

Published on: June 30, 2023

Related Experiment Videos

Last Updated: Jul 6, 2026

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy
07:47

Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy

Published on: July 9, 2016

Using Live Cell STED Imaging to Visualize Mitochondrial Inner Membrane Ultrastructure in Neuronal Cell Models
08:48

Using Live Cell STED Imaging to Visualize Mitochondrial Inner Membrane Ultrastructure in Neuronal Cell Models

Published on: June 30, 2023

Area of Science:

  • Cardiovascular Science
  • Mitochondrial Biology
  • Pathogenesis Research

Background:

  • Atherosclerosis pathogenesis involves classical risk factors and oxidative stress.
  • Oxidative stress arises from reactive oxygen and nitrogen species.
  • It leads to cellular damage, mitochondrial dysfunction, and apoptosis.

Purpose of the Study:

  • To review the role of oxidative stress in atherosclerosis.
  • To highlight the impact of oxidative stress on vascular components and mitochondria.
  • To discuss potential therapeutic strategies targeting redox homeostasis.

Main Methods:

  • Literature review of oxidative stress mechanisms in atherosclerosis.
  • Analysis of cellular and molecular damage pathways.
  • Evaluation of experimental therapeutic approaches.

Main Results:

  • Oxidative stress causes lipid peroxidation and mitochondrial damage.
  • Endothelial cells, smooth muscle cells, and erythrocytes are affected.
  • Apoptosis is induced via intrinsic and extrinsic pathways.

Conclusions:

  • Atherosclerosis results from multiple pathogenetic mechanisms.
  • Oxidative stress and mitochondrial dysfunction are central to pathogenesis.
  • Experimental agents targeting redox balance offer therapeutic potential.