Cutaneous necrosis complicating the injection of pegylated interferon alpha-2b in a patient with chronic hepatitis C

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The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

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Published on: February 3, 2012

Paolo Rosina1, Giampiero Girolomoni

  • 1Clinica Dermatologica Università di Verona, Piazzale A. Stefani 1, 37126 Verona, Italy. prosina@yahoo.com

Acta Dermatovenerologica Croatica : ADC
|March 25, 2008
PubMed

Pegylated interferon alpha (PEG-IFN-alpha) is a formulation of recombinant human interferon conjugated with polyethylene-glycol. This preparation has a long half-life (compared with conventional IFN), which allows for once-weekly injection. Elimination half-life of PEG-IFN-alpha 2b is 22-60 hours (average, 35-40 hours). We report the development of a local necrotizing reaction complicating subcutaneous injection of PEG-IFN in a patient with hepatitis C. This case enhances the need of careful training in drug reconstitution and self injection, with as much variation as possible of the injection site.

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