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Related Experiment Video

Updated: Jul 6, 2026

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

Extracellular gadolinium-based contrast media: an overview.

Marie-France Bellin¹, Aart J Van Der Molen

¹Department of Radiology, University Paris-Sud 11, University Hospital Paul-Brousse, Villejuif Cedex, France. marie-france.bellin@pbr.aphp.fr

European Journal of Radiology

|March 25, 2008

Summary

Gadolinium-based contrast agents (Gd-CA) enhance MRI imaging but carry risks. This review details their function, properties, and potential adverse events, including nephrotoxicity.

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An Aptamer-based Sensor for Unchelated Gadolinium(III)

An Aptamer-based Sensor for Unchelated Gadolinium(III)

Published on: January 9, 2017

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Last Updated: Jul 6, 2026

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

An Aptamer-based Sensor for Unchelated Gadolinium(III)

An Aptamer-based Sensor for Unchelated Gadolinium(III)

Published on: January 9, 2017

Area of Science:

Radiology and Medical Imaging
Pharmacology
Nephrology

Background:

Extracellular MRI contrast agents are increasingly used to improve diagnostic information by altering tissue T1 relaxation times.
Gadolinium-based contrast agents (Gd-CA) are widely administered intravenously for enhanced magnetic resonance imaging (MRI).

Purpose of the Study:

To provide a comprehensive overview of gadolinium-based contrast agents (Gd-CA).
To discuss the mechanism of action, pharmacokinetics, and adverse events associated with Gd-CA.

Main Methods:

Literature review of current status, mechanism, chemistry, pharmacokinetics, dosage, elimination, nephrotoxicity, and adverse events of Gd-CA.

Main Results:

Gd-CA function by shortening T1 relaxation times, providing diagnostic information.
Gd-CA are associated with various adverse reactions, including acute and delayed systemic effects, and local injection site issues.
Nephrotoxicity, such as contrast-induced nephropathy and nephrogenic systemic fibrosis, are significant concerns.

Conclusions:

Gd-CA are effective diagnostic tools but require careful consideration of their associated risks.
Understanding the properties and potential adverse events of Gd-CA is crucial for safe clinical practice.
Further research and monitoring are necessary to mitigate the risks associated with Gd-CA use.