Related Experiment Video
Updated: Jul 6, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Novel thiosemicarbazone derivatives as potential antitumor agents: Synthesis, physicochemical and structural
Ivica Dilović1, Mirta Rubcić, Visnja Vrdoljak
1Faculty of Science, Chemistry Department, Horvatovac 102(a), 10000 Zagreb, Croatia.
Abstract:
The paper describes synthesis of several novel thiosemicarbazone derivatives. Furthermore, crystal and molecular structure of 4-diethylamino-salicylaldehyde 4-phenylthiosemicarbazone revealed planarity of conjugated aromatic system, which suggested the possibility of DNA binding by intercalation, especially for here studied naphthalene derivatives. However, here presented DNA binding studies excluded this mode of action. Physicochemical and structural properties of novel derivatives were compared with previously studied analogues, taken as reference compounds, revealing distinctive differences. In addition, novel thiosemicarbazone derivatives (1, 2 and 5-8) clearly display stronger antiproliferative activity on five tumor cell lines than the reference compounds 3 and 4, which supports their further investigation as potential antitumor agents.
Related Concept Videos
Inhibitors of Bacterial DNA Synthesis
Antiviral Nucleoside Inhibitors
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Mutagenicity and Carcinogenicity
Preparation and Reactions of Sulfides
