Evaluation and management of seizures in the patient with cancer

Seizures are common in patients with cancer. They can be caused by the tumor itself, metabolic disturbances, radiation injury, chemotherapy-related encephalopathies, cerebral infarctions, or central nervous system infections. Evaluation requires a meticulous history and search for the precipitating cause. Treatment is directed at the underlying etiology and entails the rational and precise use of anticonvulsant drugs.