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Related Experiment Video

Updated: May 5, 2026

Recordings of Neural Circuit Activation in Freely Behaving Animals

Recordings of Neural Circuit Activation in Freely Behaving Animals

Published on: July 23, 2009

Some vertebrates go with the GLO.

Marie-Berengere Troadec¹, Jerry Kaplan

¹Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.

|March 25, 2008

Summary

This summary is machine-generated.

Humans cannot synthesize vitamin C (ascorbate) and must obtain it from their diet. Red blood cells adapt by preferring dehydroascorbate (DHA) uptake via Glut1, an evolutionary response to low vitamin C levels.

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Area of Science:

Biochemistry
Cell Biology
Evolutionary Biology

Background:

Most vertebrates can produce vitamin C (ascorbate) from glucose, but humans and some mammals lack this ability, requiring dietary intake.
This inability to synthesize ascorbate necessitates alternative mechanisms for acquiring the essential nutrient.

Discussion:

Erythrocytes (red blood cells) in ascorbate-dependent species alter their glucose transporter Glut1's substrate preference.
Glut1 shifts from transporting glucose to dehydroascorbate (DHA), the oxidized form of vitamin C, facilitating its uptake.

Key Insights:

The membrane protein stomatin plays a crucial role in mediating this substrate preference switch in Glut1.
This adaptation represents an evolutionary strategy to cope with vitamin C deficiency in certain mammalian lineages.

Outlook:

Understanding this mechanism provides insights into nutrient transport regulation and evolutionary adaptations.
Further research could explore the therapeutic implications of manipulating DHA uptake in conditions of vitamin C deficiency.