Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromatin dynamics and gene positioning.

R Ileng Kumaran1, Rajika Thakar, David L Spector

  • 1Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA.

Cell
|March 25, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome Editing Technologies for Cancer Therapy.

Current gene therapy·2026
Same author

Patient-derived organoid xenografts reveal the multifaceted role of the lncRNA <i>MALAT1</i> in breast cancer progression.

bioRxiv : the preprint server for biology·2026
Same author

A sub-set of guanine- and cytosine-rich genes are actively transcribed at the nuclear lamin B1 region.

Cellular and molecular life sciences : CMLS·2026
Same author

Longitudinal tracking of <i>MALAT1</i> level over a breast cancer patient's course of treatment and disease progression.

Molecular therapy. Oncology·2025
Same author

Loss of BPTF restores estrogen response and suppresses metastasis of mammary tumors.

Nature communications·2025
Same author

On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions.

bioRxiv : the preprint server for biology·2025
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Same journal

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Cell·2026
See all related articles

The cell nucleus organizes genes dynamically. Actin and myosin influence gene movement and expression, impacting nuclear organization and activity.

Area of Science:

  • Cell Biology
  • Genetics
  • Molecular Biology

Background:

  • The mammalian cell nucleus regulates gene expression through genome organization and protein interactions.
  • Gene dynamics and interchromosomal interactions are key areas of research.
  • The roles of actin and myosin in chromatin dynamics are increasingly recognized.

Purpose of the Study:

  • To review current understanding of interphase genome dynamics.
  • To discuss the impact of genome dynamics on nuclear organization.
  • To explore the relationship between genome dynamics and gene activity.

Main Methods:

  • Literature review of recent investigations.
  • Discussion of experimental findings on chromatin dynamics.
  • Synthesis of data on nuclear organization and gene regulation.

Related Experiment Videos

Main Results:

  • Specific genes exhibit high dynamism within the nucleus.
  • Actin and myosin are implicated in regulating chromatin movement.
  • Genome organization significantly influences gene expression.

Conclusions:

  • Understanding genome dynamics is crucial for comprehending nuclear organization.
  • Actin and myosin play significant roles in gene regulation.
  • Interphase genome dynamics impact overall gene activity and nuclear function.