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Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased by a...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
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Mechanism of Antibiotic Resistance in MRSA

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Related Experiment Video

Updated: Jul 6, 2026

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
07:10

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues

Published on: February 19, 2019

A Lemierre syndrome variant caused by Staphylococcus aureus.

Etienne Puymirat1, Matthieu Biais, Fabrice Camou

  • 1Service de Réanimation Médicale, Hôpital Saint-André, CHU Bordeaux, rue Jean Burguet, 33000 Bordeaux, France.

The American Journal of Emergency Medicine
|March 25, 2008
PubMed
Summary

Lemierre syndrome, a rare condition involving internal jugular vein thrombosis after infection, was successfully treated in a young woman. Prompt diagnosis and combined antibiotic, heparin, and surgical intervention led to complete recovery.

Related Experiment Videos

Last Updated: Jul 6, 2026

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
07:10

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues

Published on: February 19, 2019

Area of Science:

  • Otolaryngology
  • Infectious Diseases
  • Vascular Surgery

Background:

  • Lemierre syndrome is a rare but serious condition.
  • It is characterized by internal jugular vein thrombosis following an oropharyngeal infection.
  • Early recognition and intervention are crucial for patient outcomes.

Observation:

  • A 22-year-old woman presented with facial cellulitis.
  • Her condition rapidly worsened, leading to septic shock and multiple organ failure.
  • Computed tomography revealed thrombosis of bilateral internal and external jugular veins.

Findings:

  • The patient received a combination of antibiotics and heparin.
  • Surgical excision of vascular lesions and ligation of jugular veins were performed.
  • This comprehensive treatment led to the patient's complete recovery from infection.

Implications:

  • This case highlights the importance of considering Lemierre syndrome in patients with severe infections and neck/facial swelling.
  • Aggressive, multi-modal treatment, including surgical intervention, can be effective in managing this rare condition.
  • Prompt diagnosis and management are critical to prevent severe complications such as septic shock and organ failure.