mAtNOS1 regulates mitochondrial functions and apoptosis of human neuroblastoma cells
Mordhwaj S Parihar1, Arti Parihar, Zhonghai Chen
1Department of Surgery, Davis Heart & Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Abstract:
mAtNOS1 is a novel gene recently reported in mammalian cells with functions that are not fully understood. The present study generated human neuroblastoma SHSY cells over- and underexpressing mAtNOS1 and shows that mAtNOS1 is involved in regulating mitochondrial nitric oxide, mitochondrial transmembrane potential, protein tyrosine nitration, cytochrome c release, and apoptosis of those cells.
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