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Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Ischemic Stroke ll: Pathophysiology01:15

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

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Related Experiment Video

Updated: Jul 6, 2026

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke
09:41

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Published on: October 1, 2020

Plasticity and repair in the post-ischemic brain.

Massimiliano Di Filippo1, Alessandro Tozzi, Cinzia Costa

  • 1Clinica Neurologica, Università degli Studi di Perugia, Ospedale S Maria della Misericordia, Via S Andrea delle Fratte, Perugia, Italy.

Neuropharmacology
|March 25, 2008
PubMed
Summary

Stroke recovery involves brain plasticity, where synaptic changes like ischemia-induced long-term potentiation (i-LTP) can aid or hinder neuronal network adaptation and neurorehabilitation.

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Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
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Last Updated: Jul 6, 2026

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09:41

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Published on: October 1, 2020

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08:22

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Published on: July 21, 2013

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Neurology

Background:

  • Stroke is a leading cause of death and disability worldwide.
  • Ischemic injuries often result in permanent neurological deficits.
  • Brain plasticity plays a crucial role in recovery after stroke.

Purpose of the Study:

  • To review molecular and synaptic mechanisms of ischemia-induced synaptic plasticity.
  • To analyze adaptive and detrimental effects of these changes on neuronal networks.
  • To consider implications for post-stroke recovery and neurorehabilitation.

Main Methods:

  • Review of in vitro studies on oxygen and glucose deprivation (ischemia).
  • Analysis of synaptic transmission efficacy and long-term potentiation (i-LTP).
  • Examination of molecular and cellular mechanisms underlying plasticity.

Main Results:

  • In vitro ischemia induces long-term potentiation (i-LTP), affecting synaptic efficacy.
  • i-LTP can promote adaptive reorganization of cortical maps.
  • i-LTP may also have detrimental effects, potentially facilitating excitotoxicity via glutamate neurotransmission.

Conclusions:

  • Ischemia-induced synaptic plasticity, including i-LTP, has dual effects on neuronal networks.
  • Understanding these mechanisms is vital for optimizing neurorehabilitation strategies.
  • Brain plasticity offers potential for functional recovery in stroke survivors.